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KMID : 0604520160420030303
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Journal of the Society of Cosmetic Scientists of Korea
2016 Volume.42 No. 3 p.303 ~ p.309
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Development of Pre-assessment Indicator for Skin Aging and Anti-aging Effect of Inner Skin by the Cream Product Containing Gynostemma pentaphyllum Gypenoside Fraction
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Kim Ju-Yeon
Kim Jung-Yun
Choi Chi-Ho
Lim Joo-Hyuck
Choo Min-Joo
Moon Sung-Ho
Chang Shin-Jae
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Abstract
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The human skins had a lot of changes as aging. The synthesis of collagens and elastic fibers were reduced and the expression of matrix metalloproteinase (MMPs) was increased in the dermis. These changes have been known to be responsible for skin wrinkle formation. In this study, we tried to develop pre-indicator of inner skin aging, and investigated the effect of the cream product containing Gynostemma pentaphyllum gypenoside fraction (Gynostemma pentaphyllum gypenoside cream). 21 ∼ 34 years old 52 Korean female volunteers without crow’s feet were chosen for this clinical study. The starting point of inner skin aging was confirmed through dermal density measurement, even though outside skin wrinkles were not observed. In addition, 4 and 8 weeks treatment of G. pentaphyllum gypenoside cream significantly increased age-related reduction of dermal density. These results suggest that the evaluation of dermal density can be used as pre-indicator of skin aging. Furthermore, G. pentaphyllum gypenoside fraction is a potential anti- wrinkle agent for prevention and treatment of skin aging.
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KEYWORD
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inner skin aging, dermal density, G. pentaphyllum gypenoside fraction, pre-indicator of skin aging, anti-wrinkle
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